We are a clinical research team working in the Department of Psychological Medicine at the University of Wales College of Medicine. We are researching into the genetics (inheritance) of schizophrenia. The aim is to try and find genes which make some people more susceptible than others to becoming ill. We hope that our study will improve our understanding of mental illness and help other workers find better treatments.

Psychiatric illness sometimes runs in families but in other cases only one member of a family is affected. Unfortunately no-one understands enough about the illness to know what makes particular individuals become ill.

Our research is funded by the MRC (Medical Research Council). Because of the complex nature of schizophrenia we need as many families as possible in which there are two or more living siblings diagnosed with schizophrenia or schizoaffective disorder and resident in the UK.

Participation involves an interview, the completion of a questionnaire, and giving a sample of blood or a mouthwash. If you would like more information or would like to participate please give us a call on 01222-743058; fax 01222-746554; e-mail wpcrds@cardiff.ac.uk; or write to Dr Geraldine McCarthy, Neuropsychiatric Genetics Unit, Divisions of Psychological Medicine and Medical Genetics, Tenovus Building, Heath Park, Cardiff, CF4 4XN.

Clinical Trials of New Medication for Schizophrenia

If you or someone you know has been diagnosed with Schizophrenia and:

Is between the ages of 18 and 65 years

Has not responded to treatment with antipsychotic medication

Has not been treated with clozapine or risperidone

then you may be interested in participation in a research study to test the safety and effectiveness of an investigational medication.

Nationwide sites which are conducting this study include:

Boston, MA; Houston, TX; Far Rockaway, NY; San Diego, CA; San Antonio, TX; Milledgeville, GA

Nationwide sites soon to be conducting this study include: Dallas, TX Nashville, TN Oklahoma City, OK East Orange, NJ Taunton, MA Detroit, MI Richmond, VA Indian, IN Jackson, MS San Diego, CA (2 Sites) Cincinnati, OH Mission Hills, CA Philadelphia, PA Napa, CA Cleveland, OH New Orleans, LA New York, NY (2 Sites) Reno, NV Orange, CA Gainesville, FL Las Vegas, NV

For more information see the following web page: http://www.clinicaltrials.com/schiz.html

Interested individuals may link to patient registry and fill out the on-line form or call our toll-free automated registry line at: Phone: 1(888)trial 11