Schizophrenia – What is Schizophrenia
and Causes - Molecular and Genetic Factors
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File Source: NIMH, US Government
File Date: Tuesday, March 30, 2004
Author/Sponsor: Michael Egan and Chris Austin
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The Science of Schizophrenia Play
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File Source: National Public Radio
File Date: July 31, 1998
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In this hour, we'll take a look at the science of schizophrenia, the
challenges of treating people with this disease, and how the legal system
deals with the mentally ill. Studio guests include the Executive Director
of NAMI in Arlington, VA, the Director of Psychiatric Research at UC
Irvine medical school, and the Executive Director of the Mental Health
Association of Southeastern Pennsylvania.
The Genetics of Schizophrenia Play
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File Source: National Public Radio
File Date: May 6, 1999
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link that says "Morning Edition audio."
Study linking schizophrenia with a genetic component in DNA. It's not
a new idea--scientists have been studying it for a decade at least--but
now the focus is on families where schizophrenia occurs more frequently.
The families are Ashkenazi Jews, and they are not united in their support
for the study.
Schizophrenic Mice - Genetically Altered Rodents
Teach Scientists About Disorder Play
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File Source: National Public Radio
File Date: March 3, 2003
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More than two million people in the United States have schizophrenia,
yet the disorder remains a medical mystery. Scientists don't know precisely
what causes some brains to produce hallucinations, delusions and disordered
thinking. One reason it's particularly hard to study schizophrenia is
that it doesn't seem to occur in animals. But as NPR's Jon Hamilton
reports, a small group of scientists at the National Institutes of Health
are using genetic engineering to reproduce some of the symptoms of schizophrenia
-- in mice. Note: When you click on the link below, a new window will
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link that says "Morning Edition Radio."
The Neuroscience and Mental Illness Play
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File Source: NIMH, US Government
File Length: 5 Hours, 22 minutes
File Date: Wednesday, May 30, 2001
Speakers: R. Wyatt, D. Weinberger, S. Hyman, S. Snyder, P. Goldman-Rakic,
B. Hoffer, F. Bloom, L. DeLisi, R. Desimone, W. Freed, J. Grebb, D.
Luchins, J. Kleinman, K. Berman, S. Potkin, L. DeLisi
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Closed Worlds - Studying the Biology of Isolated
Populations Play
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File Source: BBC Radio
File Date: April 15, 2003
In the last few years, Iceland has been put on the biotech map, with
the founding of Decode Genetics, a company started by entrepreneurial
businessman, Kari Steffanson. He believes that the unique genetic qualities
of the Icelandic people, coupled with the meticulous medical and geneological
records that the country has kept will lead to the discovery of genes
associated with many common diseases such as stroke, diabetes, schizophrenia
and heart disease.
Intervention trials of EFAs in Schizophrenia.
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File Source: NIMH, US Government
File Date: April 15, 2003
Author/Sponsor: Malcolm Peet, M.D., University of Sheffield, U.K.
Total Running Time: 21:27 minutes
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Psychiatric Genetics: A Current Perspective
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File Source: UCLA grand rounds
File Date: Nov 28, 2002
Speaker: Kenneth S. Kendler, MD, Director, Virginia Institute for Psychiatric
and Behavioral Genetics
According to the genetic epidemiologist, a person's risk for psychiatric
disorder is made up of three factors: genetic makeup, family environment,
and individual environment. Dr. Kendler gives a review of two central
paradigms in psychiatric genetics (genetic epidemiology and gene-finding
methods), to address the central question of how genes raise a person's
risk of developing a psychiatric problem.
The Revolution in Psychiatric Genomics: The
Coming Era of New Treatments and Diagnoses
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File Source: UCLA grand rounds
File Date: Oct 30, 2001
Speaker: John Kelsoe, MD, Associate Professor of Psychiatry, University
of California, San Diego.
Although great strides have been made in the last 20 years thanks to
the growing field of neuroscience, psychiatrists and patients alike
would still like to see drugs with greater efficacy, fewer side effects,
more rapid action, and a more predictable effect on patients. Dr. Kelsoe
talks about how the genomics field will hopefully usher in some of these
changes, introducing a new way of practicing psychiatry in the next
50 years.
Executive Function as a Core Feature
of Schizophrenia Play
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File Source: University of Chicago grand rounds
File Date: April 2001
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Speaker Ivan J. Torres, PhD talks about the role of "executive
function" (psychological processes necessary for goal-oriented
behavior, control and regulation of behavior, and novel problem solving)
in schizophrenia. Some research suggests that it could account for some
of the disorder's broad, generalized deficits.
The Anatomy of Attention and Schizophrenia
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File Source: UCLA grand rounds
File Date: April 22, 2003
Speaker: Robert Bilder, Ph.D., Visiting Professor, Psychiatry and Biobehavioral
Sciences; Chief, Medical Psychology-Neuropsychology, Neuropsychiatric
Institute, David Geffen School of Medicine, University of California,
Los Angeles.
Dr. Bilder introduces the "dual-trends" theory of the anatomy
of attention, and highlights schizophrenia as an example of an attentional
auto-regulation disorder. NOTE: this talk is very dense and technical
from an anatomical and neurological standpoint. Appropriate for the
viewer who has more than a passing interest (and experience) with neurobiology.
Psychopathology and Drug Discovery for Schizophrenia
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File Source: UCLA grand rounds
File Date: Jan 27, 2004
Speaker: William T. Carpenter, Jr., MD, Professor of
Psychiatry and Pharmacology, University of Maryland School of Medicine,
Director, Maryland Psychiatric Research Center.
Dr. Carpenter takes a psychopathology approach to schizophrenia; he
describes what psychopathologists feel schizophrenia is as a disorder,
and the way that it should be treated.. He identifies three "domains"
of the disease - psychosis, negative, and interpersonal - that he feels
should be researched and treated as separate entities, even though they
can clinically overlap.
Can Neuroimaging Be Used to Improve the
Diagnosis of Schizophrenia?
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File Source: University of Chicago grand rounds
File Date: Oct 20, 2003
Speakers: John G. Csernansky, MD; Gregory B. Couch, Professor
of Psychiatry and Associate Professor of Neurobiology, Washington University.
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The objectives of the presentation are: (1) to review recent current
findings of neuroanatomical abnormalities in patients with schizophrenia,
and; (2) to present new findings in brain structure abnormalities in
schizophrenia patients, obtained using computer algorithms for anatomical
analysis.
Early
Schizophrenia Screening Test 
